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Year : 2019  |  Volume : 57  |  Issue : 3  |  Page : 240-242

Aftermath of topiramate: An interesting case report and literature review

Department of Glaucoma Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India

Correspondence Address:
Dr. Vijayalakshmi A Senthilkumar
Department of Glaucoma, Aravind Eye Hospital, Madurai, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/tjosr.tjosr_73_19

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We report an interesting case report on idiosyncratic reaction of topiramate causing bilateral secondary acute angle-closure glaucoma with glaukomflecken, which mimicked acute primary angle closure (APAC) with nongranulomatous uveitis and choroidal effusions. After conservative management, signs and symptoms stabilized within 72 h, but the patient developed posterior synechiae with intermittent peripheral anterior synechiae (PAS) in BE, which was more prominent in LE. Here we report this case because presentation of topiramate-induced idiosyncratic reaction with glaukomflecken and subsequent resolution with posterior synechiae and PAS were rarely documented in literature. A detailed history taking and meticulous clinical evaluation helped us differentiate from APAC.

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